Comprehensive Guide to Common OTC Drug Ingredients and Their Efficacies in Japan

Introduction

When traveling to Japan, purchasing pharmaceutical and cosmetic products either as souvenirs or for proxy shopping has become increasingly popular due to their exceptional efficacy, user-friendly design, and rapid therapeutic effects.

Despite Taiwan’s comprehensive National Health Insurance system—where consultation fees typically range from TWD 180 to 250—many households prefer self-administering over-the-counter medications such as Taisho Pabron Gold A or Panadol to relieve mild cold symptoms, including fever and nasal congestion. Additionally, analgesics like EVE are commonly chosen by women as convenient, immediate solutions for headaches and menstrual pain.

However, certain active ingredients in medications such as EVE are explicitly prohibited from being imported or used in South Korea. Travelers unaware of the composition of their medications risk facing significant customs issues, including detention or fines. Understanding the ingredients commonly present in pharmaceutical products can effectively mitigate risks and prevent unnecessary complications during international travel.

Major Drugstores and Pharmacies

Welcia Pharmacy (ウエルシア薬局)
TSURUHA Drugstore (ツルハドラッグ)
Matsumoto Kiyoshi (マツモトキヨシ)
COSMOS (コスモス薬品)
SUNDRUG (サンドラッグ)
Daikoku Drug (ダイコクドラッグ)
SUGI Pharmacy (スギ薬局)

Combination Cold Remedies

Common Ingredients in Cold Medications

Antipyretic Analgesics
- Acetaminophen / アセトアミノフェン: Inhibits central prostaglandin synthesis to reduce fever and pain; adverse effects include hepatotoxicity at excessive doses and potential renal impairment with prolonged high‑dose use.
- Ibuprofen / イブプロフェン: A non‑steroidal anti‑inflammatory drug (NSAID) that suppresses cyclooxygenase activity to provide antipyretic, analgesic, and anti‑inflammatory effects; common adverse reactions include gastrointestinal discomfort, increased risk of gastric ulceration, and renal burden.
Central Cough Suppressants
- Dihydrocodeine Phosphate / ジヒドロコデインリン酸塩: Acts on the medullary cough center to suppress cough reflex; adverse effects include dependence, respiratory depression, constipation, and sedation.
- Dextromethorphan Hydrobromide Hydrate / デキストロメトルファン臭化水素酸塩水和物: Central antitussive that inhibits the cough center; adverse effects include dizziness and nausea, with potential neuropsychiatric symptoms in overdose.
- Noscapine / ノスカピン: Non‑addictive central cough suppressant suitable for dry or nocturnal cough; adverse effects include nausea, dizziness, and rare allergic reactions.
Expectorants
- Guaifenesin / グアイフェネシン: Reduces sputum viscosity and promotes bronchial secretion clearance; adverse effects may include nausea, headache, and rash.
- Guaiacol Potassium Sulfonate / グアヤコールスルホン酸カリウム: Facilitates expectoration by diluting bronchial secretions; adverse effects include gastrointestinal discomfort and headache.
- Bromhexine Hydrochloride / ブロムヘキシン塩酸塩: Breaks down mucopolysaccharide structure to enhance ciliary motility; adverse effects include gastrointestinal discomfort and rash.
- Ambroxol Hydrochloride / アンブロキソール塩酸塩: Promotes ciliary activity and mucolysis to improve sputum clearance; adverse effects include gastrointestinal discomfort and rare skin allergy.
- Glycyrrhiza Extract / カンゾウエキス: Exhibits anti‑inflammatory and expectorant properties; long‑term high‑dose use may cause edema and hypertension.
Bronchodilators
- dl‑Methylephedrine Hydrochloride / dl‑メチルエフェドリン塩酸塩: Relaxes bronchial smooth muscle and stimulates the sympathetic nervous system to relieve cough and nasal congestion; adverse effects include palpitations, hypertension, and insomnia.
Antihistamines
- Chlorpheniramine Maleate / クロルフェニラミンマレイン酸塩: First‑generation antihistamine for relief of sneezing, rhinorrhea, and nasal congestion; adverse effects include drowsiness, dry mouth, and dizziness.
- Clemastine Fumarate / クレマスチンフマル酸塩: First‑generation antihistamine indicated for allergic rhinitis and urticaria; adverse effects include drowsiness, dry mouth, and blurred vision.
Anticholinergics
- Belladonna Total Alkaloids / ベラドンナ総アルカロイド: Exhibits anticholinergic action to relax smooth muscle, relieving nasal congestion and gastrointestinal spasms; adverse effects include dry mouth, tachycardia, blurred vision, and urinary retention.
- Isopropamide Iodide / ヨウ化イソプロパミド: Inhibits glandular secretion to reduce rhinorrhea; adverse effects include dry mouth, blurred vision, and palpitations.
Antifibrinolytics / Hemostatics
- Tranexamic Acid / トラネキサム酸: Inhibits plasminogen activation to provide anti‑inflammatory and hemostatic effects, used to relieve sore throat swelling; adverse effects include nausea, vomiting, and rare thrombotic risk.
Analgesic Adjuvants
- Anhydrous Caffeine / 無水カフェイン: Inhibits cerebral vasodilation to assist in migraine relief and enhances analgesic efficacy while providing mild CNS stimulation.
Other Traditional Ingredients
- Kakkonto Extract / 葛根湯エキス: A traditional Kampo formula promoting diaphoresis and antipyresis to relieve neck and shoulder stiffness; adverse effects include gastrointestinal discomfort and skin allergy.

Taisho Pabron Gold A Granules / Tablets

Pabron Gold A (Granules) Pabron Gold A (Tablets)

Ingredient	Amount	Efficacy
グアイフェネシン Guaifenesin	60 mg	It is a non‑prescription expectorant commonly used to help expel sputum produced in the airways during acute respiratory infections.
ジヒドロコデインリン酸塩 Dihydrocodeine Phosphate	8 mg	A central cough suppressant belonging to the opioid class, with risks of dependence and respiratory depression.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
アセトアミノフェン Acetaminophen	300 mg	An antipyretic analgesic commonly used to alleviate fever and headache.
クロルフェニラミンマレイン酸塩 Chlorpheniramine Maleate	2.5 mg	A first‑generation antihistamine that relieves sneezing, rhinorrhea, and nasal congestion associated with allergies or colds.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.
リボフラビン（ビタミンB₂） Riboflavin (Vitamin B₂)	4 mg	Maintains energy metabolism and cellular health; commonly found in B‑complex vitamin supplements.

Shin Lulu-A Tablets S

新ルル-A錠s

Ingredient	Amount	Efficacy
アセトアミノフェン Acetaminophen	300 mg	An antipyretic analgesic commonly used to alleviate fever and headache.
クレマスチンフマル酸塩 Clemastine fumarate	0.44 mg	A first‑generation antihistamine indicated for alleviating symptoms of allergic rhinitis and hay fever, including rhinorrhea, sneezing, ocular and throat itching; also effective for treating pruritus and urticaria caused by allergic reactions.
ジヒドロコデインリン酸塩 Dihydrocodeine Phosphate	8 mg	A central cough suppressant belonging to the opioid class, with risks of dependence and respiratory depression.
ノスカピン Noscapine	16 mg	A non‑addictive central cough suppressant commonly used to treat dry cough and nocturnal coughing.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
グアヤコールスルホン酸カリウム Guaiacol potassium sulfonate	80 mg	Facilitates bronchial secretion clearance by liquefying sputum, making expectoration easier and relieving respiratory discomfort caused by viscous phlegm.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.
ベンフォチアミン（ビタミン B₁ 誘導体） Benfotiamine (vitamin B₁ derivative)	8 mg	A lipophilic vitamin B₁ derivative with high bioavailability, which aids in the recovery of physical strength depleted by colds and improves neural transmission.

Shin Lulu-A Gold DXα

新ルルAゴールドDXα

Ingredient	Amount	Efficacy
クレマスチンフマル酸塩 Clemastine fumarate	0.44 mg	A first‑generation antihistamine indicated for alleviating symptoms of allergic rhinitis and hay fever, including rhinorrhea, sneezing, ocular and throat itching; also effective for treating pruritus and urticaria caused by allergic reactions.
ベラドンナ総アルカロイド Belladonna total alkaloids	0.1 mg	An anticholinergic agent that relaxes smooth muscle, used to relieve rhinorrhea and nasal congestion caused by acute or allergic rhinitis. It is also indicated as adjunctive therapy for gastric and duodenal ulcers, pyloric spasms, and other gastrointestinal functional disorders.
ブロムヘキシン塩酸塩 Bromhexine hydrochloride	4 mg	Exhibits mucolytic action by reducing sputum viscosity, thereby facilitating expectoration.
トラネキサム酸 Tranexamic acid	140 mg	Inhibits the activity of the fibrinolytic enzyme plasmin, contributing to anti‑inflammatory and hemostatic effects, and helps alleviate throat swelling and pain.
アセトアミノフェン Acetaminophen	300 mg	An antipyretic analgesic commonly used to alleviate fever and headache.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
デキストロメトルファン臭化水素酸塩水和物 Dextromethorphan Hydrobromide Hydrate	16 mg	Acts on the cough center to suppress the cough reflex.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.

Estac Comprehensive Cold

エスタック総合感冒

Features: A comprehensive cold remedy suitable for family use; indicated for patients aged 5 years and older.

Ingredient	Amount	Efficacy
アセトアミノフェン Acetaminophen	300 mg	An antipyretic analgesic commonly used to alleviate fever and headache.
クロルフェニラミンマレイン酸塩 Chlorpheniramine Maleate	2.5 mg	A first‑generation antihistamine that relieves sneezing, rhinorrhea, and nasal congestion associated with allergies or colds.
デキストロメトルファン臭化水素酸塩水和物 Dextromethorphan Hydrobromide Hydrate	16 mg	Acts on the cough center to suppress the cough reflex.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
ヘスペリジン Hesperidin	15 mg	Replenishes vitamins depleted during a cold.
カンゾウエキス Glycyrrhiza Extract	63 mg	Exhibits both antitussive and expectorant effects, and also provides anti‑inflammatory relief.
ショウキョウ末 Shokyo Powder	50 mg	Promotes perspiration, aiding in the reduction of fever.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.

Colgen Kowa IB Tablets TXα

コルゲンコーワIB錠TXα

Ingredient	Amount	Efficacy
イブプロフェン Ibuprofen	200 mg	Functions via a non‑steroidal anti‑inflammatory mechanism, effectively inhibiting prostaglandin synthesis responsible for inflammation and pain, thereby relieving sore throat and reducing fever.
トラネキサム酸 Tranexamic acid	250 mg	Inhibits the activity of the fibrinolytic enzyme plasmin, contributing to anti‑inflammatory and hemostatic effects, and helps alleviate throat swelling and pain.
アンブロキソール塩酸塩 Ambroxol Hydrochloride	15 mg	Aids in the expulsion of troublesome sputum that causes coughing.
d-クロルフェニラミンマレイン酸塩 d-Chlorpheniramine Maleate	1.2 mg	A first‑generation antihistamine that relieves sneezing, rhinorrhea, and nasal congestion associated with allergies or colds.
ジヒドロコデインリン酸塩 Dihydrocodeine Phosphate	8 mg	A central cough suppressant belonging to the opioid class, with risks of dependence and respiratory depression.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.

Estac EX Neo

エスタックEXネオ

Ingredient	Amount	Efficacy
イブプロフェン Ibuprofen	200 mg	Operates via a non‑steroidal anti‑inflammatory mechanism, effectively inhibiting prostaglandin synthesis responsible for inflammation and pain, thereby relieving sore throat and reducing fever (antipyresis).
ヨウ化イソプロパミド Isopropamide Iodide	2 mg	Inhibits the action of the neurotransmitter, thereby reducing nasal secretions.
クロルフェニラミンマレイン酸塩 Chlorpheniramine Maleate	2.5 mg	A first‑generation antihistamine that relieves sneezing, rhinorrhea, and nasal congestion associated with allergies or colds.
アンブロキソール塩酸塩 Ambroxol Hydrochloride	15 mg	Facilitates the expulsion of irritating sputum that triggers coughing.
ジヒドロコデインリン酸塩 Dihydrocodeine Phosphate	8 mg	A central cough suppressant belonging to the opioid class, with risks of dependence and respiratory depression.
dl-メチルエフェドリン塩酸塩 dl-Methylephedrine Hydrochloride	20 mg	A bronchodilator and sympathomimetic agent used to relieve cough, nasal congestion, and related symptoms.
酸化マグネシウム Magnesium Oxide	100 mg	Promotes the dissolution of ibuprofen and provides gastroprotective effects on the gastric mucosa.
無水カフェイン Anhydrous Caffeine	25 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.

Kakkonto Extract Granules S Kracie

葛根湯エキス顆粒Sクラシエ

Indications: Suitable for individuals with moderate or higher physical strength for the following symptoms: early-stage common cold (before onset of sweating), nasal cold, rhinitis, headache, shoulder stiffness, muscle aches, and pain in the hands or shoulders.

Ingredient	Amount	Efficacy
葛根湯エキス Kakkonto Extract	1300 mg	Extracted from the following crude drugs: Pueraria Root 2 g, Ephedra 1 g, Jujube 1 g, Cinnamon Twig 0.75 g, Peony Root 0.75 g, Licorice 0.5 g, Ginger 0.25 g.

Rhinitis Medications

Common Ingredients in Rhinitis Medications

Analgesic Adjuvants
- Anhydrous Caffeine: Inhibits cerebral vasodilation to assist in migraine relief; also enhances analgesic efficacy and provides mild CNS stimulation.
Bronchodilators / Decongestants
- Pseudoephedrine Hydrochloride: Promotes nasal airway patency to relieve congestion.
- Phenylephrine Hydrochloride: Causes vasoconstriction of the nasal mucosa to reduce congestion and edema, providing rapid relief of nasal blockage.
Antihistamines
- Carbinoxamine Maleate: Alleviates sneezing, rhinorrhea, nasal congestion, and pruritus associated with allergic rhinitis and urticaria.
- Chlorpheniramine Maleate: A first‑generation antihistamine for relief of sneezing, rhinorrhea, and nasal congestion due to allergies or colds.
Anticholinergics
- Belladonna Total Alkaloids: Relaxes smooth muscle to relieve rhinorrhea and nasal congestion in acute or allergic rhinitis; also used as adjunctive therapy for gastrointestinal spasms.
- Datura Extract: Inhibits nasal gland secretion, effective against rhinorrhea and other rhinitis symptoms.

Taisho Pabron Rhinitis Capsules Sα

パブロン鼻炎カプセルSα

Ingredient	Amount	Efficacy
塩酸プソイドエフェドリン Pseudoephedrine Hydrochloride	60 mg	Used to relieve nasal congestion and promote nasal airway patency.
マレイン酸カルビノキサミン Carbinoxamine Maleate	6 mg	Used to alleviate sneezing, rhinorrhea, nasal congestion, and pruritus associated with allergic rhinitis, urticaria, and other allergic conditions.
ベラドンナ総アルカロイド Belladonna Total Alkaloids	0.2 mg	An anticholinergic agent that relaxes smooth muscle, used to relieve rhinorrhea and nasal congestion caused by acute or allergic rhinitis. It is also indicated as adjunctive therapy for gastric and duodenal ulcers, pyloric spasms, and other gastrointestinal functional disorders.
無水カフェイン Anhydrous Caffeine	50 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.

Sato Pharmaceutical STONARHINI S Rhinitis Granules

ストナリニS

Ingredient	Amount	Efficacy
クロルフェニラミンマレイン酸塩 Chlorpheniramine Maleate	6 mg + 6 mg	A first‑generation antihistamine that relieves sneezing, rhinorrhea, and nasal congestion associated with allergies or colds.
フェニレフリン塩酸塩 Phenylephrine Hydrochloride	6 mg + 6 mg	The nasal mucosal blood vessels constrict, reducing congestion and edema, providing rapid relief from nasal congestion symptoms.
ダツラエキス Datura Extract	12 mg + 12 mg	Inhibits nasal secretion and is effective in treating symptoms of rhinitis, such as runny nose.

Throat / Cough Medication

Common Ingredients in Throat and Cough Medications

Cough Suppressant / Expectorants
- Platycodon Powder: Has cough-suppressing and expectorant properties, and helps treat respiratory-related diseases such as pharyngitis and abscess.
- Senega officinalis Powder: Promotes the expulsion of phlegm and alleviates respiratory discomfort, aligning with its expectorant function.
- Glycyrrhiza Powder: Suppresses cough, expels phlegm, and has anti-inflammatory and gastric mucosal protective effects. It is commonly used in Traditional Chinese Medicine to treat respiratory diseases.
- Apricot Kernel Powder: Bitter almond extract in northern apricot seeds has cough-suppressing and expectorant properties but should be used cautiously due to its toxicity. Southern apricot is milder and more focused on moisturizing the lungs and stopping coughing.
- Ginseng Powder: Possesses anti-inflammatory and immune-regulating effects, helping to alleviate coughing and repair throat mucosa.
- Powdered Gambir: Has mild anti-inflammatory properties, protects the throat mucosa, and promotes self-cleansing functions.
Anti-inflammatory / Hemostatic Agents
- Tranexamic Acid: Inhibits fibrinolytic enzyme activity, with anti-inflammatory and hemostatic effects, reducing throat swelling and pain.
- Azulene Sulfonate Sodium Hydrate: Inhibits the release of inflammatory mediators, has anti-inflammatory and analgesic properties, and alleviates throat mucosal swelling and pain.
Antimicrobial / Antiseptics
- Iodine: Has broad-spectrum antimicrobial effects, quickly sterilizing and killing viruses, but should be used cautiously in children, as it may temporarily affect thyroid function, especially in premature infants or children with immature thyroid glands.
- Povidone-Iodine: Releases free iodine ions continuously, providing long-lasting antimicrobial effects with relatively low irritation. Though safer for infants in lower concentrations, caution should still be taken regarding potential thyroid effects in newborns and premature infants.
- Cetylpyridinium Chloride Hydrate: Reduces the local pathogen load by disrupting pathogen cell membranes and acts quickly on viruses. It is safe at appropriate concentrations (usually not exceeding 1000 μg/mL), but overuse should be avoided.

Ryukakusan Direct Stick

Ryukakusan Mint Powder Ryukakusan Peach Powder Ryukakusan Mango Throat Lozenges

Ingredient	Amount	Efficacy
キキョウ末 Platycodon Powder	84 mg	Platycodon, a common traditional Chinese medicine, holds significant medicinal value. It primarily serves as a cough suppressant, expectorant, and pus expeller, often used to treat symptoms like coughing, excessive phlegm, tonsillitis, pharyngitis, and abscesses.
セネガ末 Senega officinalis Powder	4.2 mg	It promotes the expulsion of phlegm, helping to clear the respiratory tract and alleviate discomfort caused by phlegm accumulation.
カンゾウ末 Glycyrrhiza Powder	102 mg	With cough-suppressing, expectorant, and throat-relaxing properties, it effectively alleviates severe coughing, sore throat, and airway discomfort. Additionally, it offers multiple benefits, including anti-inflammatory, immune-regulating, and gastric mucosal protection effects.
キョウニン末 Apricot kernel Powder	15 mg	Apricot kernels contain amygdalin, which acts on the cough center, effectively alleviating coughing.
ニンジン末 Ginseng Powder	84 mg	It enhances immunity, has anti-inflammatory effects, relieves coughing and phlegm accumulation, and nourishes and repairs the throat mucosa.
アセンヤク末 Powdered Gambir	8.4 mg	With mild anti-inflammatory properties, it protects the throat mucosa, relieves coughing, and promotes the self-cleansing function of the throat.

Perac T Fine Granules Cool

ペラックT細粒クール

Ingredient	Amount	Efficacy
トラネキサム酸 Tranexamic Acid	750 mg	Inhibits the activity of the fibrinolytic enzyme plasmin, contributing to anti‑inflammatory and hemostatic effects, and helps alleviate throat swelling and pain.
カンゾウ乾燥エキス Glycyrrhiza Dry Extract	198 mg	Has cough-suppressing and expectorant properties, and can alleviate inflammation.
ピリドキシン塩酸塩 Pyridoxine Hydrochloride	50 mg	Participates in amino acid metabolism, red blood cell production, and aids in the synthesis of neurotransmitters.
リボフラビン Riboflavin	12 mg	Participates in lipid and protein metabolism, and helps maintain the health of the skin and mucous membranes.
L-アスコルビン酸ナトリウム Sodium Ascorbate	500 mg	Helps promote the normal functioning of the skin and mucous membranes.

Kobayashi Pharmaceutical

のどぬ～るスプレー

100 ml 中：

Ingredients	スプレー	スプレー EXクール	スプレーキッズ	スプレークリアミント	ナイテクト	Efficacy
ヨウ素 Iodine	0.5 g	0.5 g	－	－	－	Has broad-spectrum antimicrobial activity, quickly and effectively eliminating various bacteria and viruses.
ポビドンヨード Povidone-Iodine	－	－	0.45 g	－	－	A gentle formula designed for children, releasing free iodine ions continuously for long-lasting broad-spectrum antibacterial effects with reduced mucosal irritation, suitable for preschool and school-aged children.
セチルピリジニウム塩化物水和物（塩化セチルピリジニウム） Cetylpyridinium Chloride	－	－	－	0.3 g	0.3 g	Disrupts pathogen cell membranes to exert antimicrobial effects, reducing the pathogen load in the oropharynx and helping relieve local inflammation and discomfort.
アズレンスルホン酸ナトリウム水和物 Sodium Gualenate Hydrate	－	－	－	－	0.02 g	Inhibits the release of inflammatory mediators, has anti-inflammatory and analgesic effects, effectively alleviating swelling and pain of the throat mucosa.

Nisshin Throat Inflammation Tablets

オラキュア錠

Ingredient	Amount	Efficacy
トラネキサム酸 Tranexamic acid	250 mg	Inhibits the activity of the fibrinolytic enzyme plasmin, contributing to anti‑inflammatory and hemostatic effects, and helps alleviate throat swelling and pain.
カンゾウ乾燥エキス Glycyrrhiza Dry Extract	66 mg	Has cough-suppressing and expectorant properties, and can alleviate inflammation.
ピリドキシン塩酸塩（ビタミンB₆） Pyridoxine Hydrochloride (Vitamin B₆)	16.67 mg	Participates in amino acid metabolism, red blood cell production, and aids in the synthesis of neurotransmitters.
リボフラビン（ビタミンB₂） Riboflavin (Vitamin B₂)	4 mg	Maintains energy metabolism and cellular health; commonly found in B‑complex vitamin supplements.
L-アスコルビン酸ナトリウム Sodium Ascorbate	166.67 mg	Helps promote the normal functioning of the skin and mucous membranes.

Painkillers

Common Painkiller Ingredients

Antipyretic Analgesics
- アセトアミノフェン / Acetaminophen: Inhibits the synthesis of prostaglandins in the central nervous system to achieve antipyretic and analgesic effects; side effects include liver toxicity risk from overdose, and prolonged high doses may cause kidney damage.
- イブプロフェン / Ibuprofen: A nonsteroidal anti-inflammatory drug that inhibits enzyme activity in the body responsible for inflammation and pain, thereby reducing prostaglandin production. It has antipyretic, analgesic, and anti-inflammatory effects. Common side effects include gastrointestinal discomfort, increased risk of ulcers, and kidney strain.
Analgesic Adjuvants
- アリルイソプロピルアセチル尿素 / Allylisopropylacetylurea: Has a sedative synergistic effect and can enhance the analgesic effect of ibuprofen by inhibiting cerebral vasodilation; may cause significant drowsiness, so driving or operating machinery should be avoided after use. Recommended for patients 15 years and older; not recommended for children or pregnant women.
Adjuvant Pain-Relieving Ingredients
- 無水カフェイン / Anhydrous Caffeine: Inhibits cerebral vasodilation and helps alleviate migraines; also enhances the effect of painkillers and has a stimulating effect.

EVE

EVE A Tablets
EVE A Tablets EX
EVE Quick Headache Medicine DX
EVE Three Shot Premium

EVE is a comprehensive analgesic brand developed and marketed by Japan’s SS Pharmaceutical since 1985. It is primarily designed to relieve various chronic and acute pain conditions, including headaches, menstrual pain, and joint discomfort. Widely available as an over-the-counter analgesic, EVE products are notable for their rapid effectiveness and diverse formulation, with multiple variants tailored to different therapeutic needs.

Certain EVE products (such as EVE A and EVE Quick) contain the ingredient Allylisopropylacetylurea, a substance legally permitted in Japan with analgesic and central nervous system depressant properties. However, according to South Korea’s Narcotics Control Act Enforcement Decree, this ingredient is classified as a psychotropic substance, making its importation or possession strictly prohibited.

Effective April 2025, South Korea will impose a complete ban on importing or bringing any medications containing Allylisopropylacetylurea into the country. Violators will have their items confiscated and destroyed by customs officials and will incur a record of the violation.

Ingredients	EVE A Tablets	EVE A Tablets EX	EVE Quick Headache Medicine DX	EVE Three Shot Premium	Efficacy
Ibuprofen	150 mg	200 mg	200 mg	195 mg	Inhibits the synthesis of prostaglandins, achieving analgesic, antipyretic, and anti-inflammatory effects.
Acetaminophen	－	－	－	195 mg	Reduces pain and fever by inhibiting the transmission of pain signals in the central nervous system.
Magnesium Oxide	－	－	100 mg	70 mg	Enhances drug absorption rate, reduces gastric irritation, and improves drug stability.
Allylisopropylacetylurea	60 mg	60 mg	60 mg	－	Exhibits synergistic sedative effects, enhancing the analgesic action of ibuprofen by inhibiting cerebral vasodilation. May cause significant drowsiness; it is advised to avoid driving or operating machinery after administration. For use only by individuals aged 15 and above; not recommended for children or pregnant women. Prohibited from entry into South Korea by law.
Anhydrous Caffeine	80 mg	80 mg	80 mg	65 mg	Inhibits cerebral vasodilation, helping to relieve migraines.

BUFFERIN PREMIUM DX

Ingredient	Amount	Efficacy
イブプロフェン Ibuprofen	160 mg	Operates via a non‑steroidal anti‑inflammatory mechanism, effectively inhibiting prostaglandin synthesis responsible for inflammation and pain, thereby relieving sore throat and reducing fever (antipyresis).
アセトアミノフェン Acetaminophen	160 mg	It is the main analgesic and antipyretic ingredient, capable of inhibiting the synthesis of prostaglandins in the central nervous system, reducing pain and inflammation, but without anti-inflammatory effects.
無水カフェイン Anhydrous Caffeine	50 mg	A central nervous system stimulant that promotes alertness and enhances the efficacy of antipyretic analgesics.
乾燥水酸化アルミニウムゲル Dried Aluminum Hydroxide Gel	70 mg	It has acid-neutralizing, gastric mucosal protective effects, and helps prevent the formation of urinary tract stones.

Gastrointestinal Medication

Wakamoto Tablets

Strong Wakamoto

In 27 tablets (adult daily dosage):

Ingredient	Amount	Efficacy
アスペルギルス･オリゼーNK菌（消化酵素産生菌）培養末 Aspergillus oryzae	3375 mg	A strain that produces digestive enzymes (e.g., amylase, protease), promoting the breakdown and absorption of food, enhancing digestive efficiency.
乳酸菌培養末 Lactic Acid Bacteria Culture Powder	675 mg	Inhibits harmful bacteria in the intestines and regulates gastrointestinal function.
乾燥酵母（ビール酵母） Dried Yeast (Brewer’s Yeast)	2490.1 mg	Rich in natural B vitamins, amino acids, and minerals (e.g., zinc, chromium, iron), with high bioavailability, effectively supplementing essential nutrients needed by the body.
チアミン硝化物（ビタミンB₁） Thiamine Nitrate (Vitamin B₁)	3.4 mg	Promotes carbohydrate metabolism and maintains the function of the nervous system.
リボフラビン（ビタミンB₂） Riboflavin (Vitamin B₂)	2 mg	Involved in lipid and protein metabolism, helping to maintain the health of skin and mucous membranes.
ニコチン酸アミド Niacinamide	2 mg	Aids in energy production and blood circulation.

Shinbyo Feiming S

新ビオフェルミンS錠

In 9 tablets (adult daily dosage):

Ingredient	Amount	Efficacy
コンク・ビフィズス菌末 Concentrated B. bifidum powder	18 mg	Maintains the balance of intestinal flora, promotes bowel movement, and improves smooth defecation.
コンク・フェーカリス菌末 Concentrated S. faecalis powder	18 mg	Enhances intestinal immunity, inhibits the growth of harmful bacteria, and improves digestive function.
コンク・アシドフィルス菌末 Concentrated L. acidophilus powder	18 mg	Assists in lactose breakdown, increases the proportion of beneficial bacteria in the gut, and alleviates gastrointestinal discomfort.

Vitamin B Complex Supplements

Vitamin B Complex Comparison

Alinamin
1. Each product contains 100 mg of furanthiamine (a derivative of Vitamin B₁), which has excellent absorption and high bioavailability, mainly enhancing energy metabolism and reducing fatigue.
2. EX Plus and EX Plus α contain higher doses of B₆ (100 mg) and B₁₂ (1500 μg), suitable for those with higher metabolic needs or noticeable fatigue.
3. Medical Gold: Contains active B₆ (pyridoxal 5’-phosphate) and natural Vitamin E, plus 1 mg of folic acid (B₉) and 1500 μg of methylcobalamin (Vitamin B₁₂), aiding in nerve repair and red blood cell production.
4. A50: Lower overall dosage with relatively lower B₆ and B₁₂ content, suitable for initial supplementation or basic needs.
Chocola BB Plus
1. Focuses on skin and mucous membrane health, with riboflavin phosphate (Vitamin B₂ phosphate) 38 mg at the core, and also contains 50 mg of B₆ and 20 mg of B₁. It is particularly effective for mouth ulcers, rough skin, mucous membrane repair, and energy production.
2. Contains niacinamide (B₃), which helps maintain normal skin and mucous membrane function, and provides support for those with recurring angular cheilitis, dull skin, or skin fatigue.

Vitamin B Complex Key Functions

Vitamin B₁ (Thiamine or its derivatives): Improves energy metabolism and helps alleviate fatigue.
Vitamin B₂ (Riboflavin): Maintains skin, mucous membrane, and eye health, and participates in energy metabolism. Suitable for dry skin, angular cheilitis, and similar conditions.
Vitamin B₃ (Niacin / Niacinamide): Maintains the normal function of skin and mucous membranes. Regulates sebum secretion and strengthens the stratum corneum, assisting with acne, dryness, and itching. High doses may cause flushing; it is recommended to take in divided doses or after meals.
Vitamin B₆ (Pyridoxine): Metabolism of proteins and neurotransmitters. The daily upper limit for adults is approximately 25 mg, and long-term daily intake exceeding 100 mg may cause neurotoxicity. It is advised to monitor daily intake limits.
Vitamin B₉ (Folic Acid): Involved in nucleic acid synthesis and cell division, promotes red blood cell production, and reduces the risk of megaloblastic anemia; especially important for pregnant women, as it helps fetal neural tube development.
Vitamin B₁₂ (Cobalamin): Red blood cell production and nerve cell protection.

If you are particularly concerned about fatigue, neuropathic pain, or require high-intensity metabolic support, consider products with higher doses of B₁, B₆, and B₁₂. If your focus is on skin and mucous membrane care, look for formulas containing B₂ (especially the phosphate ester form) and B₃.

Alinamin

Alinamin A Alinamin EX Plus Alinamin EX Plus α Alinamin Medical Gold Alinamin A50

Ingredient Comparison

Adult daily dosage:

Ingredients	A	EX Plus	EX Plus α	Medical Gold	A50
フルスルチアミン（ビタミンB₁誘導体） Fursultiamine	100 mg	100 mg	100 mg	100 mg	100 mg
ピリドキシン塩酸塩（ビタミンB₆） Pyridoxine Hydrochloride (Vitamin B₆)	20 mg	100 mg	100 mg	－	10 mg
ピリドキサールリン酸エステル水和物（活性型ビタミンB₆） Pyridoxal 5'-Phosphate Monohydrate （Active Form of Vitamin B₆）	－	－	－	60 mg	－
シアノコバラミン（ビタミンB₁₂） Cyanocobalamin（Vitamin B₁₂）	60 μg	1500 μg	1500 μg	－	20 μg
メコバラミン（ビタミンB₁₂） Mecobalamin（Vitamin B₁₂）	－	－	－	1500 μg	－
リボフラビン（ビタミンB₂） Riboflavin (Vitamin B₂)	12 mg	－	10 mg	－	10 mg
トコフェロールコハク酸エステルカルシウム（ビタミンE） Calcium Tocopheryl Succinate	－	103.58 mg	103.58 mg	－	－
コハク酸d-α-トコフェロール（天然型ビタミンE） Vitamin E Succinate	－	－	－	100 mg	－
パントテン酸カルシウム Calcium Pantothenate	15 mg	30 mg	30 mg	－	－
ガンマーオリザノール Gamma Oryzanol	－	10 mg	10 mg	10 mg	－
葉酸 Folic Acid	－	－	－	1 mg	－

Ingredient Description

Ingredient Name	Efficacy
Furanthiamine (Vitamin B₁ Derivative)	High absorption rate and bioavailability, rapidly converted into active Vitamin B₁, promotes carbohydrate metabolism and energy generation, alleviates fatigue, and boosts physical strength.
Pyridoxine Hydrochloride (Vitamin B₆)	Participates in amino acid metabolism, red blood cell production, and aids in the synthesis of neurotransmitters.
Pyridoxal 5’-phosphate (Active Form of Vitamin B₆)	The active form of Vitamin B₆, works without conversion, suitable for those with poor metabolic function.
Cyanocobalamin (Vitamin B₁₂)	Promotes red blood cell formation, maintains the function of the nervous system, and supports energy metabolism.
Riboflavin (Vitamin B₂)	Acts as a coenzyme in energy metabolism and antioxidants, maintaining skin, mucous membranes, nerves, and eye health.
Vitamin E (Calcium Succinate Derivative)	Esterified with calcium succinate to form a stable compound, antioxidant, anti-inflammatory, reduces cardiovascular and cancer risks.
Vitamin E (Natural Form)	Natural d-α-tocopherol, with high antioxidant activity and bioavailability, delays aging, and promotes immune and cardiovascular health.
Pantothenic Acid (Vitamin B₅)	Involved in carbohydrate, lipid, and protein metabolism, assists in energy production and physiological maintenance.
Oryzanol	Extracted from brown rice oil, with antioxidant properties, regulates the autonomic nervous system, improves menopause symptoms, and aids in lipid metabolism.
Folic Acid (Vitamin B₉)	Promotes red blood cell production, improves anemia, works synergistically with B₁₂ to repair nerve damage, enhances metabolism and circulation.

Chocola BB Plus Coated Tablets

チョコラBBプラス

Ingredient	Amount
リボフラビンリン酸エステルナトリウム（ビタミンB₂リン酸エステル） Riboflavin Phosphate Sodium（Vitamin B₂ Phosphate）	38 mg
ピリドキシン塩酸塩（ビタミンB₆） Pyridoxine Hydrochloride (Vitamin B₆)	50 mg
チアミン硝化物（ビタミンB₁硝酸塩） Thiamine Nitrate (Vitamin B₁ Nitrate)	20 mg
ニコチン酸アミド Niacinamide	40 mg
パントテン酸カルシウム Calcium Pantothenate	20 mg

Ingredient Name	Efficacy
Riboflavin Sodium Phosphate (Vitamin B₂ Phosphate)	Assists in energy release and maintenance of skin and mucous membranes.
Pyridoxine Hydrochloride (Vitamin B₆)	Assists in protein metabolism and maintains the nervous system.
Thiamine Nitrate (Vitamin B₁)	Helps maintain energy metabolism and nervous system function.
Niacinamide (Vitamin B₃)	Promotes energy production and helps maintain skin health.
Pantothenic Acid (Vitamin B₅)	Involved in nutrient metabolism, maintaining normal bodily functions.

Eczema / Atopic Dermatitis Medication

Common Eczema / Atopic Dermatitis Medication Ingredients

Anti-itch
- クロタミトン / Crotamiton: Has anti-itch properties, commonly used to relieve itching associated with eczema, dermatitis, etc. Side effects may include local irritation or mild redness and swelling in some cases.
Local Anesthesia
- リドカイン / Lidocaine: A local anesthetic that can inhibit nerve conduction, providing rapid relief from pain and itching. Side effects may include local skin reactions or a brief tingling sensation.
Antihistamine
- ジフェンヒドラミン / Diphenhydramine: An antihistamine used to relieve skin symptoms caused by allergic reactions, such as redness, itching, and hives. Side effects may include local dryness or mild stinging.
Antioxidant
- トコフェロール酢酸エステル / Tocopherol Acetate: An antioxidant that promotes skin repair and protects against dryness and roughness. Side effects are rare but may include an oily or greasy feeling on the skin.
Anti-inflammatory
- グリチルレチン酸 / Glycyrrhetinic Acid: A steroid-like anti-inflammatory that soothes redness and sensitivity. Rare cases may experience mild stinging.
- グリチルリチン酸一アンモニウム / Ammonium Glycyrrhizinate: Anti-inflammatory that helps relieve dryness and itching. Side effects are rare, but mild allergic reactions may occur.
Moisturizing and Keratolytic
- Urea: Used for moisturizing and softening keratin, effective in treating dryness and hyperkeratosis. Side effects may include mild local stinging or a burning sensation.
Vitamins
- レチノール / Retinol: Promotes epidermal cell turnover, anti-aging, improves fine lines, and evens skin tone. Side effects may include photosensitivity, dryness, or mild peeling.
- エルゴカルシフェロール / Ergocalciferol: Regulates skin immunity, provides anti-inflammatory effects, and promotes barrier repair. Side effects are rare but may cause local irritation at high doses.
Antibacterial
- トリクロカルバン (T.C.C.) / Triclocarban: An antibacterial agent used to inhibit the growth of surface bacteria and reduce the risk of infection. Side effects may include dryness or mild irritation.
Physical Protection
- 酸化亜鉛 / Zinc Oxide: Provides physical protection, with antibacterial, anti-inflammatory, and astringent properties, promoting wound healing. Side effects may include occasional dryness or white residue left on the skin.

Mentholatum AD Cream

メンソレータム ADクリーム

Contains per 1 g:

Ingredient	Amount	Efficacy
クロタミトン Crotamiton	50 mg	Has anti-itch properties, commonly used to relieve itching associated with eczema, dermatitis, etc.
リドカイン Lidocaine	20 mg	A local anesthetic that can inhibit nerve conduction, providing rapid relief from pain and itching.
ジフェンヒドラミン Diphenhydramine	50 mg	An antihistamine used to relieve skin symptoms caused by allergic reactions, such as redness, itching, and hives.
トコフェロール酢酸エステル Tocopherol Acetate	5 mg	An antioxidant that promotes skin repair and effectively protects against dryness and rough skin.
グリチルレチン酸 Glycyrrhetinic Acid	2 mg	An anti-inflammatory ingredient with steroid-like effects but no side effects, suitable for soothing redness and sensitivity.

Mentholatum AD Lotion

メンソレータム AD乳液